Hyaluronan, commonly referred to as Hyaluronic acid, is a major component of skin, where it is involved in tissue repair. When skin is exposed to excessive UVB rays, it becomes inflamed, or sunburned, and the cells in the dermis stop producing as much hyaluronan. This can increase the rate of skin’s degradation. The skin is the largest organ in the body comprising about 15% of the body weight. Roughly 50% of the Hyaluronic acid in our body is found in the skin. Hyaluronic acid and Collagen are vital to maintaining the skin’s layers and structure. It is the collagen that gives the skin its firmness, and Hyaluronic acid that nourishes and hydrates the collagen.Hyaluronic acid is a linear biopolymer belonging to glycosaminoglycans (GAGs). Primary structure of Hyaluronic acid is constituted by a repetitive disaccharide unit of sodium glucuronate and N-acetyl glucosamine, linked by a Î² (1-3) bond. Hyaluronic acid that is 15.000 – 50.000 Da normalizes hydration. It limits trans epidermal water loss by reinforcing tight junctions between keratinocytes of the stratum granulosum.
The special Hyaluronic acid used in our Previse recipe stimulates the expression of ZO1 and Occludin proteins that are constitutive proteins of tight junctions. This improves cell cohesion and the barrier function of the skin. Moreover, thanks to the high hygroscopic ability of the Hyaluronic acid, it maintains hydration in the skin through a water reservoir function in the dermis.
Through both of these complementary actions, Hyaluronic acid regulates the internal hydration of the skin and improves firmness by stimulating collagen in the dermis.